
Small-molecule activation of TFEB alleviates Niemann–Pick disease type C via promoting lysosomal exocytosis and ...
TFEB and TFE3 are identified as key transcription factors regulating lysosome and autophagy biogenesis (Sardiello et al., 2009). To investigate the role of TFEB/TFE3 in cellular cholesterol levels in NPC1 cells, HeLa cells were treated with U18666A (2. …